منابع مشابه
Physics of ion channels.
We review the basic physics involved in transport of ions across membrane channels in cells. Electrochemical forces that control the diffusion of ions are discussed both from microscopic and macroscopic perspectives. A case is made for use of Brownian dynamics as the minimal phenomenological model that provides a bridge between experiments and more fundamental theoretical approaches. Applicatio...
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Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances regulate T cell activation as well as neuronal function and thus have been found to play a crucial role in MS pathogenesis. Since present therapeutical approaches are only parti...
متن کاملo 13: ion channels in autoimmune neurodegeneration
multiple sclerosis (ms) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. ionic conductances regulate t cell activation as well as neuronal function and thus have been found to play a crucial role in ms pathogenesis. since present therapeutical approaches are only parti...
متن کاملIon Channels
Ion channels catalyze the transmembrane movement of small inorganic ions across biological membranes. They do so by forming continuous, hydrophilic pores through which ions can cross the barrier imposed by the lipid bilayer hydrophobic core. Ion channels serve many functions: they underlie the changes in membrane potential that control many cell functions, including the propagated electrical si...
متن کاملBiogenesis of Ion Channels
Amphiphilic lipids can form effective barriers between a cell and the outside world. However, they obstruct the movements of ions into and out of the cell, which are essential to cellular life. The earliest cells, called protocells, had ‘leaky’ monolayers or bilayers composed of single-chain amphiphilic lipids that would have permitted the passage of ions. However, as these lipid barriers evolv...
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ژورنال
عنوان ژورنال: Journal of Biological Physics
سال: 2003
ISSN: 0092-0606
DOI: 10.1023/a:1027309113522